A UK study has shown that a vaccine can protect people against paratyphoid fever. Paratyphoid fever affects over two million people globally each year. Yet no licensed vaccine is currently available. The clinical trial involved six UK sites, including University Hospital Southampton. Volunteers took part locally at the NIHR Southampton Clinical Research Facility (CRF). The new oral vaccine was shown to provide significant protection. There weren’t any safety concerns. ‘Major

A human challenge trial has shown a new vaccine could offer better protection against whooping cough.   This follows a new report that highlights that 2024 whooping cough numbers were at their worst in 30 years.   Whooping cough is a serious and sometimes deadly disease. It affects millions of people worldwide each year.   Vaccines for whooping cough are already part of routine childhood immunisations in the UK. However they don’t provide lifelong protection. They also don’t

Southampton researchers are leading an international project on a potential new treatment for a serious threat in hospitals. They have found it in a surprising location - hospital toilets. The team have comprehensively catalogued a new collection of bacteria-eating viruses called phages. They have sourced these, in part, from hospital wastewater. These phages could potentially be used to treat one of the world’s most dangerous hospital superbugs. Serious threat to patients Th

Professor Tristan Clark is one of six new outstanding research leaders chosen to address urgent health challenges in the UK. He has been appointed as an NIHR Research Professor. The  Professorship will provide up to £2 million to deliver ambitious, translational research. Professor Clark is a leading expert in infectious diseases. His research is reducing unnecessary antibiotic use in acute respiratory infection through rapid diagnostic tests. He is a professor at the Univer

Researchers in Southampton are part of a new Translational Research Collaboration (TRC) in Infection and Antimicrobial Resistance (AMR). The new network will rally research communities across the UK to help fight infections. It is backed by the National Institute for Health and Care Research (NIHR). Southampton’s Professor Robert Read will co-lead one of the TRC’s core workstreams. This will expand early-phase vaccine research. It will also help identify correlates of protect

Ros Gough and her son Eddie University Hospital Southampton and primary care services are leading a trial to test the nasal flu vaccine in one-year-old children . The FluSNIFF study is inviting families to take part at around 100 GP practices across the UK. Three hospital sites are also taking part. The trial is being led by co-chief investigators Professor Saul Faust and Dr Alasdair Munro from the NIHR Southampton Clinical Research Facility. It is exploring whether the nasal

Dr Callum Highmore is a first author on the new paper Southampton researchers have shown a technique they developed could rapidly...

Discoveries by Southampton researchers on how bacteria defend themselves against viruses could be key to tackling antibiotic resistance....

Ceri and Harry took part in a clinical trial at University Hospital Southampton. Thousands of premature babies at risk of serious...

Southampton researchers are improving how people who experience recurrent urinary tract infections (UTIs) are supported. UTIs usually...

Investigating bacterial samples taken from cystic fibrosis patients Southampton researchers   are enlisting the public to become citizen...

An innovative vaccine that doesn’t need to be refrigerated or frozen has entered its first clinical trial.   The Stablepharma...

A rapid test to help treat bacterial infections is taking a major step following a funding boost. The iFAST test can help patients get...

A study has shed new light on the movement of bacteria during pregnancy. Pregnant women given nose drops containing harmless bacteria did...

Southampton researchers are calling for stricter regulations on antimicrobials to protect public health. Antimicrobial chemicals are...

A promising blood test does not reduce the time children in hospital have antibiotics, according to a ground-breaking UK study. Overuse...

Southampton researcher Dr Hannah Schiff has won a prestigious national prize. Dr Schiff is the winner of the 2024 British Thoracic...

An art project promoting vaccines in pregnancy was showcased in London last month. Visitors of all ages interacted with the Clothed with...

Southampton researchers are leading a study to improve the treatment of urinary tract infections (UTIs) in care homes. Antibiotic...

A new trial will see if a vaccine can protect babies against a common respiratory virus from birth. The trial, known as RSVoyage, is...