Dr Chrissie Jones
BMedSci BMBS PgcertHBE FHEA FRCPCH PhD
Associate Professor and Honorary Consultant in Paediatric Infectious Diseases
Dr Jones' research interests focus on interventions in pregnancy to prevent infection in early life.
She is an international expert in maternal vaccination and has led pertussis, RSV and COVID-19 vaccine clinical trials in pregnancy. She is the co-director of IMPRINT (imprint-network.co.uk), a global network of experts in vaccination.
Dr Jones leads studies to reduce the risk of CMV acquisition in pregnancy and is engaging with policy makers to integrate CMV education into routine antenatal care in the UK. She leads the Wessex perinatal infection service and serves as medical advisor to the charity CMV Action.
Jones, C. E., Calvert, A., Southern, J., Matheson, M., Andrews, N., Khalil, A., et al. (2021). A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants. BMC Medicine, 19(1), 138–11. http://doi.org/10.1186/s12916-021-02005-5
RECOVERY Collaborative Group (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637–1645. http://doi.org/10.1016/S0140-6736(21)00676-0
Flood, J., Shingleton, J., Bennett, E., Walker, B., Amin-Chowdhury, Z., Oligbu, G., … Jones, C.E… Ladhani, S. (2021).
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. The Lancet Regional Health. Europe, 3, 100075. http://doi.org/10.1016/j.lanepe.2021.100075
Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., et al. (2020). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. The Lancet Child & Adolescent Health, 1–10. http://doi.org/10.1016/S2352-4642(20)30304-7
Whittaker, E., Bamford, A., Kenny, J., Kaforou, M., Jones, C. E., Shah, P., et al. (2020). Clinical Characteristics of 58 Children with a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020;324(3):259-269
Ramasamy, M. N., Minassian, A. M., Ewer, K. J., Flaxman, A. L., Folegatti, P. M., Owens, D. R., et al. (2021). Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet, 396(10267), 1979–1993. http://doi.org/10.1016/S0140-6736(20)32466-1
Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S.. on behalf of the Oxford COVID Vaccine Trial Group (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet, 396(10249), 467–478. http://doi.org/10.1016/S0140-6736(20)31604-4
Madhi, S. A., Polack, F. P., Piedra, P. A., Munoz, F. M., Trenholme, A. A., Simões, E. A. F., et al. (2020). Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants. The New England Journal of Medicine, 383(5), 426–439. http://doi.org/10.1056/NEJMoa1908380
Tregoning, J. S., Weiner, J., Cizmeci, D., Hake, D., Maertzdorf, J., Kaufmann, S. H. E., ….Jones, C.E..(2020). Pregnancy has a minimal impact on the acute transcriptional signature to vaccination. Npj Vaccines, 5(1), 436. http://doi.org/10.1038/s41541-020-0177-6
Eckert, L. O., Jones, C. E., Kachikis, A., Bardají, A., Silva, F. T. D., Absalon, J., et al. (2020). Obstetrics risk Assessment: Evaluation of selection criteria for vaccine research studies in pregnant women. Vaccine, 38(29), 4542–4547.
Vandrevala, T., Barber, V., Calvert, A., Star, C., Khalil, A., Griffiths, P., et al. (2019). Understanding pregnant women's readiness to engage in risk-reducing measures to prevent infections during pregnancy. Journal of Health Psychology, 1359105319884609. http://doi.org/10.1177/1359105319884609
Wilcox, C. R., Calvert, A., Metz, J., Kilich, E., MacLeod, R., Beadon, K., et al. (2019). Determinants of Influenza and Pertussis Vaccination Uptake in Pregnancy: A Multicenter Questionnaire Study of Pregnant Women and Healthcare Professionals. The Pediatric Infectious Disease Journal, 38(6), 625–630. http://doi.org/10.1097/INF.0000000000002242
Retzler, J., Hex, N., Bartlett, C., Webb, A., Wood, S., Star, C., …Jones, C.E. (2019). Economic cost of congenital CMV in the UK. Archives of Disease in Childhood, 104(6), 559–563. http://doi.org/10.1136/archdischild-2018-316010
Wilcox, C. R., Calvert, A., Metz, J., Kilich, E., MacLeod, R., Beadon, K., et al. (2019). Attitudes of Pregnant Women and Healthcare Professionals Toward Clinical Trials and Routine Implementation of Antenatal Vaccination Against Respiratory Syncytial Virus. The Pediatric Infectious Disease Journal, 1–8. http://doi.org/10.1097/INF.0000000000002384
O'Sullivan, C. P., Lamagni, T., Patel, D., Efstratiou, A., Cunney, R., Meehan, M., et al. (2019). Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014-15: a prospective surveillance study. The Lancet Infectious Diseases, 19(1), 83–90. http://doi.org/10.1016/S1473-3099(18)30555-3
Jones, C. E., Munoz, F. M., Spiegel, H. M. L., Heininger, U., Zuber, P. L. F., Edwards, K. M., et al. (2016). Guideline for collection, analysis and presentation of safety data in clinical trials of vaccines in pregnant women. Vaccine, 34(49), 5998–6006. http://doi.org/10.1016/j.vaccine.2016.07.032
Jones, C. E., Munoz, F. M., Kochhar, S., Vergnano, S., Cutland, C. L., Steinhoff, M., et al. (2016). Guidance for the collection of case report form variables to assess safety in clinical trials of vaccines in pregnancy. Vaccine, 1–8. http://doi.org/10.1016/j.vaccine.2016.07.007
Ladhani, S. N., Andrews, N. J., Southern, J., Jones, C. E., Amirthalingam, G., Waight, P. A., et al. (2015). Antibody Responses After Primary Immunization in Infants Born to Women Receiving a Pertussis-containing Vaccine During Pregnancy: Single Arm Observational Study With a Historical Comparator. Clinical Infectious Diseases, 61(11), 1637–1644. http://doi.org/10.1093/cid/civ695
Jones, C. E., Hesseling, A. C., Tena-Coki, N. G., Scriba, T. J., Chegou, N. N., Kidd, M., et al. (2015). The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination. Aids, 29(2), 155–165. http://doi.org/10.1097/QAD.0000000000000536
Jones, C. E., Naidoo, S., De Beer, C., Esser, M., Kampmann, B., & Hesseling, A. C. (2011). Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected Infants. The Journal of the American Medical Association, 305(6), 576–584. http://doi.org/10.1001/jama.2011.100
Primary prevention of cytomegalovirus in pregnancy: addressing the gaps: NIHR PRP; PI: 2020 - 2021; £146,958.
IMmunising PRegnant women and INfants neTwork (IMPRINT); GCRF/UKRI: Co-PI with Professor Beate Kampmann: £2.5million; 2017-2021
Optimising the Timing of whooping cough Immunisation in MUMs (OptiMUM); Thrasher Research Fund and NISEC (DoH); Co-I to Professor Paul Heath; £450,700; 2018-2021
A Study to Evaluate the Efficacy of Maternal Immunization with RSV F Vaccine in Preventing RSV Lower Respiratory Tract Infection in Young Infants: Novavax; PI; £135,886: 2017-2019
Evaluation and Validation of GAIA Maternal Immunization Outcome Definitions: National Vaccine Programme Office (NVPO); Co-applicant; £250,000; 2017-2018
Reducing Acquisition of CMV through antenatal Education (RACE FIT): NIHR; CI; £290,770; 2016-2020
Recent impacts include: the first randomised controlled trial of a digital intervention in pregnancy to reduce the risk of CMV infection which paves the way for inclusion of CMV risk reduction as part of antenatal care; and the evaluation of pertussis vaccines in pregnancy (iMAP1 and iMAP2) which were considered by JCVI when recommending the continuance of pertussis vaccination programme in pregnancy in the UK.