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Dr Angela Darekar


Head of MRI Physics, UHS Lead for Imaging Research

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Angela is the Head of MRI Physics, within the Department of Medical Physics at University Hospital Southampton (UHS). She is passionate about facilitating and encouraging the use and translation of advanced MRI techniques within the clinical research setting, working closely with clinical colleagues and using her expertise in MRI physics to successfully enable this. 

She has also taken on the role of UHS Lead for Imaging Research, to further develop and establish this broader area of research in Southampton. Angela is the Chair of the NIHR Imaging Research Delivery workstream and a member of the NIHR Imaging Group steering committee.

Landmark publications:

Galea I, Durnford A, Glazier J, Mitchell S, Kohli S, Foulkes L, Norman J, Darekar A, Love S, Bulters DO, Nicoll JAR, Boche D (2022) Iron deposition in the brain after aneurysmal subarachnoid haemorrhage. Stroke May;53(5):1633-1642

Hou R, Beardmore R, Holmes C, Osmond C, Darekar AA (2021) A case-control study of the locus coeruleus degeneration in Alzheimer's disease. Eur Neuropsychopharmacol Jan 8;S0924-977X(21)00003-1

King AJ, Dudderidge TJ, Darekar A, Schmizt K, Heard R, Everitt C, Chambers R, Breen DJ (2019) Establishing MRI guided prostate intervention at a UK Centre. British Journal of Radiology, Jun; 92(1098):20180918

Kija EN, Saunders DE, Munubhi E, Darekar A, Barker S, Cox TCS, Mango M, Soka D, Komba J, Nkya DA, Cox SE, Kirkham FJ, Newton CRJC. (2019) Transcranial Doppler and Magnetic Resonance in Tanzanian children with sickle cell disease Stroke. Jul; 50(7):1719-1726

Varatharaj A, Liljeroth MG, Darekar AA, Larsson HBW, Galea I, and Cramer SP (2018) Blood-brain barrier permeability measured using dynamic contrast-enhanced magnetic resonance imaging: a validation study. Journal of Physiology, Feb; 597(3):699-709

Puzzo I, Seunarine K, Sully K, Darekar A, Clark C, Sonuga-Barke EJS and Fairchild G (2017) Altered White-Matter Microstructure in Conduct Disorder is Specifically Associated with Elevated Callous-Unemotional Traits. Journal of Abnormal Child Psychology. Oct;46(7):1451-1466

Darekar AA, Schreglmann, M, Joy, HM; Gawne-Cain M, Kirkham FJ, Vollmer B (2016) Susceptibility-Weighted Magnetic Resonance Imaging (SWI) in Newborns with Hypoxic-Ischemic Encephalopathy Neuropediatrics; Issue S 01; P08-07

Webb AL, Darekar AA, Sampson M, Rassoulian H. (2009) Synovial folds of the lateral atlantoaxial joints: in vivo quantitative assessment using magnetic resonance imaging in healthy volunteers. Spine (Phila Pa 1976). Sep 1; 34(19):E697-702

Major grants:

Co-I, Characterisation of anatomical and functional brain networks in newborns with neonatal hypoxic-ischaemic encephalopathy – proof of concept study. University of Southampton Institute for Life Sciences (IfLS) Research Stimulus Fund – £18,451

Co-I, Gaining new insight into the pathogenesis of Alzheimer’s disease: investigating the role of the locus coeruleus using neuromelanin-sensitive MRI. Alzheimer’s Research UK Pilot Project – £49,989

Co-I, A feasibility study into the use of novel MRI techniques for paediatric lung disease. Asthma, Allergy and Inflammation Research - £9800

Co-I, Neurodevelopmental trajectories and neural correlates in children with neonatal Hypoxic-Ischaemic Encephalopathy (HIE). Action Medical Research - £180,783

PI, Validation of the use of MRI for image guided cryoablation. Institute of Physics and Engineering in Medicine Innovation Grant - £6620

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