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Professor Stuart Clarke

Msc, PhD, FFPH, FRCPath

Professor of Microbiology and Public Health
Honorary Consultant in Public Health

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Professor Clarke has research interests in the epidemiology of infectious diseases, particularly in relation to vaccine development and the evaluation of new vaccines. He works mostly with Streptococcus pneumoniae and Haemophilus influenzae both in the UK and across Southeast Asia.

In 2009, Dr Clarke won the Bupa Foundation's award of ‘Best Emerging Medical Researcher in the UK’ for his work on the molecular epidemiology of pneumococcal infection around the introduction of pneumococcal conjugate vaccines.

He is also an Adjunct Associate Professor at the International Medical University in Kuala Lumpur and an Associate Editor of the journal Pneumonia.

Landmark publications: 

Changes   in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between   2006 and 2018. 

Cleary DW, Jones J, Gladstone RA, Osman KL, Devine   VT, Jefferies JM, Bentley SD, Faust SN, Clarke SC.

Sci Rep. 2022 Aug 3;12(1):13332. doi:   10.1038/s41598-022-17600-6.

PMID: 35922536 Free PMC article.

Visualizing   variation within Global Pneumococcal Sequence Clusters (GPSCs) and country   population snapshots to contextualize pneumococcal isolates. 

Gladstone RA, Lo SW, Goater R, Yeats C, Taylor B,   Hadfield J, Lees JA, Croucher NJ, van Tonder AJ, Bentley LJ, Quah FX,   Blaschke AJ, Pershing NL, Byington CL, Balaji V, Hryniewicz W, Sigauque B,   Ravikumar KL, Almeida SCG, Ochoa TJ, Ho PL, du Plessis M, Ndlangisa KM,   Cornick JE, Kwambana-Adams B, Benisty R, Nzenze SA, Madhi SA, Hawkins PA,   Pollard AJ, Everett DB, Antonio M, Dagan R, Klugman KP, von Gottberg A,   Metcalf BJ, Li Y, Beall BW, McGee L, Breiman RF, Aanensen DM, Bentley SD; The   Global Pneumococcal Sequencing Consortium.

Microb Genom. 2020 May;6(5):e000357. doi:   10.1099/mgen.0.000357. Epub 2020 Apr 29.

PMID: 32375991 Free PMC article.

Pneumococcal   lineages associated with serotype replacement and antibiotic resistance in   childhood invasive pneumococcal disease in the post-PCV13 era: an   international whole-genome sequencing study. 

Lo SW, Gladstone RA, van Tonder AJ, Lees JA, du   Plessis M, Benisty R, Givon-Lavi N, Hawkins PA, Cornick JE, Kwambana-Adams B,   Law PY, Ho PL, Antonio M, Everett DB, Dagan R, von Gottberg A, Klugman KP,   McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

Lancet Infect Dis. 2019 Jul;19(7):759-769. doi:   10.1016/S1473-3099(19)30297-X. Epub 2019 Jun 10.

PMID: 31196809 Free PMC article.

Global   emergence and population dynamics of divergent serotype 3 CC180 pneumococci. 

Azarian T, Mitchell PK, Georgieva M, Thompson CM,   Ghouila A, Pollard AJ, von Gottberg A, du Plessis M, Antonio M,   Kwambana-Adams BA, Clarke SC, Everett D, Cornick J, Sadowy E, Hryniewicz W,   Skoczynska A, Moïsi JC, McGee L, Beall B, Metcalf BJ, Breiman RF, Ho PL, Reid   R, O'Brien KL, Gladstone RA, Bentley SD, Hanage WP.

PLoS Pathog. 2018 Nov 26;14(11):e1007438. doi:   10.1371/journal.ppat.1007438. eCollection 2018 Nov.

PMID: 30475919 Free PMC article.

Pneumococcal   vaccine impacts on the population genomics of non-typeable Haemophilus   influenzae. 

Cleary DW, Devine VT, Morris DE, Osman KL,   Gladstone RA, Bentley SD, Faust SN, Clarke SC.

Microb Genom. 2018 Sep;4(9):e000209. doi:   10.1099/mgen.0.000209. Epub 2018 Aug 6.

PMID: 30080135 Free PMC article.

Major grants: 


Clarke,   Faust, Cleary


Epidemiology   of carried and disease-causing pneumococci during pneumococcal conjugate   vaccine implementation



Clarke,   Faust, Cleary


Epidemiology   of carried and disease-causing pneumococci during pneumococcal conjugate   vaccine implementation




British   Council (Newton Fund Institutional Links Award)

Assessing   the risk of emerging microbes during vaccine implementation and climate   change through population-based carriage studies of the upper respiratory   tract in all age groups



Wilkinson,   Bourne, Clarke, Sutton


An   epidemiology study to assess the contribution of bacterial and viral   pathogens to Acute Exacerbations of Chronic Obstructive Pulmonary Disease   (AECOPD) in adults and elderly between 40 and 85 years of age in the UK



Wilkinson,   Bourne, Clarke


5 year   collaborative agreement to establish quality managed readouts of   immunometrics and molecular microbiology and to develop proof of concept for   COPD vaccine programme


Impact example:

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