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Dr Sofia Michopoulou


Consultant Clinical Scientist; NIHR Clinical Lecturer


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Dr Sofia Michopoulou is Head of Nuclear Medicine Physics and Medical Physics Expert at University Hospitals Southampton NHS Foundation Trust (UHS), where she leads the introduction of new diagnostic and therapeutic methods in Nuclear Medicine and PET.

Sofia is also an NIHR Clinical Lecturer and her research focuses on developing imaging and fluid biomarkers and using artificial intelligence for dementia diagnosis and prognosis. Sofia teaches medical imaging at BSc and MSc level at the University of Southampton and delivers part of the Fellows of Royal College of Radiology physics module.

Landmark Publications:

S. Michopoulou, A. Prosser, C. Kipps, J. Dickson, M. Guy, J. Teeling. Biomarkers of Inflammation Increase with Tau and Neurodegeneration but not with Amyloid-β in a Heterogenous Clinical Cohort. Journal of Alzheimer's Disease. DOI: 10.3233/JAD-220523, 2022.

S. Michopoulou, E. O’Shaughnessy EK. Thomson K, MJ. Guy. Discovery Molecular Imaging Digital Ready PET/CT performance evaluation according to the NEMA NU2-2012 standard. Nuclear medicine communications. 1;40(3):270-7, 2019.

E. Skoura, S. Michopoulou, M. Mohmaduvesh, E. Panagiotidis, M. Al Harbi, C. Toumpanakis, O. Almukhailed, I. Kayani, R. Syed, S. Navalkissoor, P. J Ell, M. E Caplin, J. Bomanji, “The impact of 68Ga-DOTATATE PET/CT imaging on management of patients with neuroendocrine tumors: experience from a national referral center in the United Kingdom”. Journal of Nuclear Medicine 57 (1), 34-40, 2016.

K. Moodley, D. Perani, L. Minati, P. Della Rosa, F. Pennycook, J. Dickson, A. Barnes, V. Contarino, S. Michopoulou, L. D’Incerti, C. Good, F. Fallanca, E. Vanoli, P. Ell, D. Chan “Simultaneous PET-MRI Studies of the Concordance of Atrophy and Hypometabolism in Syndromic Variants of Alzheimer’s Disease and Frontotemporal Dementia: An Extended Case Series”, Journal of Alzheimer’s Disease 46 (3), 2015.

K. Al-Nabhani, R. Syed, S. Michopoulou, J. Alkalbani, A. Afaq, E. Panagiotidis, C. O’Meara, A. Groves, P. Ell, J. Bomanji, “Qualitative and Quantitative Comparison of PET/CT and PET/MR Imaging in Clinical Practice”. Journal of Nuclear Medicine 55 (1), 88-94, 2013.

S. Michopoulou, L. Costaridou, M. Vlychou, R. Speller, A. Todd-Pokropek, “Texture-Based Quantification of Lumbar Intervertebral Disc degeneration from Conventional T2-weighted MRI”. Acta Radiologica; 52(1), 91-98, 2011.

S. Michopoulou, L. Costaridou, E. Panagiotopoulos, R. Speller, G. Panayiotakis and A. Todd-Pokropek, “Atlas-Based Segmentation of Degenerated Lumbar Intervertebral Discs from MR Images of the Spine”, IEEE Transactions in Biomedical Engineering; 56(9), 2225-31, 2009.

Major grants:

  • PI, Biomarker Research Assessing Inflammation in Neurodegeneration using Artificial Intelligence (BRAIN AI), NIHR & HEEIntegrated Clinical Academic Lectureship, £208,693

  • PI, SHAPE Post-doctoral Award, NIHR ARC Wessex & Southampton Academy of Research, £15,000

  • PI, NHS Topol Digital Fellowship, HEE £30,000

  • Co-I, Research Stimulus Fund for a pilot study on Inflammation in Dementia, Institute for Life Sciences, £15,000

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