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Prof John Primrose


Professor of Surgery

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Prof John Primrose is a globally renowned academic and Fellow of the Academy of Medical Sciences. He was elected to Academia Europea in 2021 (only UK surgeon ever), and has changed global practice in several key areas of GI cancer through landmark publications submitted as Impact Study in 2021 UK Universities REF exercise. 

He has developed a liver and pancreas surgical service with outstanding benchmarked clinical results. He was made an NIHR Senior Investigator in 2016. He joined the Medical Research Council Clinical Training Board in 2018, supporting the careers of aspirant academics. He was elected Chair for the Research Committee of the International Hepatobiliarypancreatic Association. He has Chaired two NICE Guidelines Committees, and presently Chairs the Deutsche Krebshilfe (German Cancer Aid) Translational Funding Committee. He is Editor in Chief of the Oxford Text Book of General Surgery, and is developing a text for the UK surgical training curriculum. He also mentors trainees in the Academy of Medical Sciences scheme, and rehearses applicants for UKRI/MRC/CRUK fellowships.

Landmark publications:

Primrose JN, Perera R, Gray A, Rose P, Fuller A, Corkhill A, George S, Mant D; FACS Trial Investigators. Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial. JAMA 2014 Jan 15;311(3):263-70

Bridgewater JA, Pugh SA, Maishman T, Eminton Z, Mellor J, Whitehead A, Stanton L, Radford M, Corkhill A, Griffiths GO, Falk S, Valle JW, O'Reilly D, Siriwardena AK, Hornbuckle J, Rees M, Iveson TJ, Hickish T, Garden OJ, Cunningham D, Maughan TS, Primrose JN; New EPOC investigators.  Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 2020;21(3):398-411.

Bridgewater J, Fletcher P, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Primrose J; BILCAP study group. Long-Term Outcomes and Exploratory Analyses of the Randomized Phase III BILCAP Study. J Clin Oncol. 2022 Mar 22:JCO2102568. doi: 10.1200/JCO.21.02568.

Major grants:

FACS Trial (HTA), BILCAP Trial (CRUK), New EPOC Trial (CRUK), NIHR Senior Investigator Award.

Impact example:

Impact case study in 2020 Universities Research Excellence Framework for work on changing global practice in colorectal and biliary cancer.

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