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Prof John Holloway


Professor of Allergy and Respiratory Genetics, Associate Vice President Interdisciplinary Research

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John Holloway is originally from New Zealand where he graduated from Otago University and undertook his PhD in the Malaghan Institute. He is now Professor of Allergy and Respiratory Genetics in the Faculty of Medicine and his research program focuses on genetics, epigenetics and functional genomics of allergic and respiratory diseases such as asthma and COPD. His current research includes exploring the mechanisms of prenatal programming of respiratory disease and epigenetic mechanisms underlying atopy and asthma susceptibility; gene-environment interactions in the early life origins of asthma and COPD; characterisation of genetic factors influencing asthma severity; and identification and validation of novel asthma susceptibility genes.

Landmark publications:

P Van Eerdewegh, et al. Association of the ADAM33 gene with asthma and bronchial   hyperresponsiveness

Nature 2002:418 (6896);426-430

Nwokoro C, Pandya H, Turner S, Eldridge S, Griffiths CJ, Vulliamy   T, Price D, Sanak M, Holloway JW,   Brugha R, Koh L, Dickson I, Rutterford C, Grigg J. Intermittent montelukast   in children aged 10 months to 5 years with wheeze (WAIT trial): a   multicentre, randomised, placebo-controlled trial. Lancet Respiratory Medicine. 2014;2(10):796-803

Imboden M, Wielscher M, Rezwan FI, Amaral AFS, Schaffner E, Jeong   A, Beckmeyer-Borowko A, Harris SE, Starr JM, Deary IJ, Flexeder C,   Waldenberger M, Peters A, Schulz H, Chen S, Sunny SK, Karmaus WJJ, Jiang Y,   Erhart G, Kronenberg F, Arathimos R, Sharp GC, Henderson AJ, Fu Y, Piirilä P,   Pietiläinen KH, Ollikainen M, Johansson A, Gyllensten U, de Vries M, van der   Plaat DA, de Jong K, Boezen HM, Hall IP, Tobin MD, Jarvelin MR, Holloway JW, Jarvis D, Probst-Hensch   NM. Epigenome-wide association study of lung function level and its change. European Respiratory Journal. 2019;54(1)   1900457. doi: 10.1183/13993003.00457-2019

Accordini S, Calciano L, Johannessen A, Benediktsdóttir B,   Bertelsen RJ, Bråbäck L, Dharmage SC, Forsberg B, Gómez Real F, Holloway   JW, Holm M, Janson C, Jõgi NO, Jõgi R, Malinovschi A, Marcon A,   Martínez-Moratalla Rovira J, Sánchez-Ramos JL, Schlünssen V, Torén K, Jarvis   D, Svanes C. Prenatal and prepubertal exposures to tobacco smoke in men may   cause lower lung function in future offspring: a three-generation study using   a causal modelling approach. European Respiratory Journal.   2021:2002791. doi: 10.1183/13993003.02791-2020. Epub ahead of print.

Major grants:

2011-2016 University   of Southampton Transgenerational   epigenetic inheritance of allergy in a multigenerational cohort. R01 award   from National Institutes of Health (USA) (R01 AI091905). Co-applicant and   work package leader overseeing epigenetic analysis. Total budget €2,452,165

2012-2016 COST   (European Cooperation in Science and Technology). Vice-Chair and WG1 lead   BMBS COST Action BM1201 Developmental Origins of Chronic Lung Disease.   Organising 4 annual meetings, research exchanges and work group meetings of   COST network with > 300 members. Total budget €549,906

2016-2020 University   of Memphis, USA. Does epigenetic methylation explain the gender-switch in   adolescent asthma? R01 award from National Institutes of Health (USA). Joint   Principle Investigator (with Dr H Zhang, University Memphis, USA). Total   budget €2,571,405.

2018-2023 University   of Bergen. Preconception exposures and related epigenetic mechanisms in asthma   and allergies. Norwegian Research Council. Co-applicant and work package   leader overseeing epigenetic analysis. Funds to University of Southampton   €406,537

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