Prof Jane Lucas
MD, PhD, FRCPCH, FERS
Professor of Paediatric Respiratory Medicine
Prof Lucas is a Professor of Paediatric Respiratory Medicine at University of Southampton. Jane leads the national primary ciliary dyskinesia (PCD) diagnostic centre in Southampton.
Her respiratory research is focused on understanding the pathophysiology of PCD and improving diagnosis and management of patients with this disease. She also investigates the role of ciliated respiratory epithelium in disease and health, including the interaction between cilia and pathogens.
Landmark publications:
Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK, Zhang Q, Thompson J, Lucas JS, Bingle CD, Norris DP, Roy S, Brown A. De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell. 2021 Oct 21:S0092-8674(21)01181-8.
Lucas JS, Barbato A, Collins SA, Goutaki M, Behan L, Caudri D, Dell S, Eber E, Escudier E, Hirst RA, Hogg C, Jorissen M, Latzin P, Legendre M, Leigh MW, Midulla F, Nielsen KG, Omran H, Papon JF, Pohunek P, Redfern B, Rigau D, Rindlisbacher B, Santamaria F, Shoemark A, Snijders D, Tonia T, Titieni A, Walker WT, Werner C, Bush A, Kuehni CE. European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia. Eur Respir J. 2017 Jan 4;49(1). 9
Shoemark A, Rubbo B, Legendre M, Fassad MR, Haarman EG, Best S, Bon ICM, Brandsma J, Burgel PR, Carlsson G, Carr SB, Carroll M, Edwards M, Escudier E, Honoré I, Hunt D, Jouvion G, Loebinger MR, Maitre B, Morris-Rosendahl D, Papon JF, Parsons CM, Patel MP, Thomas SN, Thouvenin G, Walker WT, Wilson R, Hogg C, Mitchison HM, Lucas JS. Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia. Eur Respir J. 2021 Jan 21:2002359. doi: 10.1183/13993003.02359-2020.
Blume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin JM, Frank M, Butler J, Crispin M, Coles J, Thompson J, Ridley RA, Dean LSN, Loxham M, Reikine S, Azim A, Tariq K, Johnston DA, Skipp PJ, Djukanovic R, Baralle D, McCormick CJ, Davies DE*, Lucas JS*, Wheway G*, Mennella V*. A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection. Nat Genet. 2021 Jan 11. doi: 10.1038/s41588-020-00759-x. * Corresponding author
Behan L, Dimitrov BD, Kuehni CE, Hogg C, Carroll M, Evans HJ, Goutaki M, Harris A, Packham S, Walker WT, Lucas JS. PICADAR: a diagnostic predictive tool for primary ciliary dyskinesia. Eur Respir J. 2016 Apr;47(4):1103-12.
HE. Kobbernagel, FF. Buchvald, EG. Haarman, C Casaulta, SA. Collins, C Hogg, CE. Kuehni, JS. Lucas, CE. Moser, AL. Quittner, S Rosthøj, AL. Sørensen, K Thomsen, C Werner, H Omran, KG. Nielsen. Efficacy and safety of azithromycin maintenance therapy in primary ciliary dyskinesia (BESTCILIA): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial. Lancet Respir Med. 2020 May;8(5):493-505.
Lucas JS, Davis SD, Omran H, Shoemark A. Primary ciliary dyskinesia in the genomics age. Lancet Respir Med. 2019 Oct 14. pii: S2213-2600(19)30374-1. doi:10.1016/S2213-2600(19)30374-1.
Jackson CL, Behan L, Collins SA, Goggin PM, Adam EC, Coles JL, Evans HJ, Harris A, Lackie P, Packham S, Page A, Thompson J, Walker WT, Kuehni C, Lucas JS. Accuracy of diagnostic testing in primary ciliary dyskinesia. Eur Respir J. 2016 Mar;47(3):837-48.
Goutaki M, Maurer E, Halbeisen FS, Amirav I, Barbato A, Behan L, Boon M, Casaulta C, Clement A, Crowley S, Haarman E, Hogg C, Karadag B, Koerner-Rettberg C, Leigh MW, Loebinger MR, Mazurek H, Morgan L, Nielsen KG, Omran H, Schwerk N, Scigliano S, Werner C, Yiallouros P, Zivkovic Z, Lucas JS, Kuehni CE; PCD Italian Consortium.; Swiss PCD Group.; French Reference Centre for Rare Lung Diseases.; Genetic Disorders of Mucociliary Clearance Consortium. The international primary ciliary dyskinesia cohort (iPCD Cohort): methods and first results. Eur Respir J. 2017 Jan 4;49(1).
Lucas JS, Behan L, Dunn Galvin A, Alpern A, Morris AM, Carroll MP, Knowles MR, Leigh MW, Quittner AL. A quality-of life measure for adults with primary ciliary dyskinesia: QOL-PCD. Eur Respir J. 2015 Aug;46(2):375-83.
Examples of impact:
Jane has developed and coordinated a number of international networks bringing together multidisciplinary clinicians and scientists to improve the diagnosis and management of PCD. Examples of impact include the first evidenced based guidelines for the diagnosis of PCD, understanding of genotype phenotype associations, the first clinical trial in this patient group and tools to improve the diagnosis and monitoring of patients.