Guo Cheng

Dr Guo Cheng

PhD, MBCHB

Research Fellow

Gc1a20@soton.ac.uk

ORCID ID

Profile page(s)

Guo Cheng is a bioinformatician and statistical geneticist, and works as a research fellow.

Guo works on genomics and other omics data from the Southampton cohort of complex diseases, the UK Biobank (data on autoimmune conditions), and Genomics England, and excels at integrating this with clinical phenotypes. Before joining the University of Southampton, Guo worked on cancer omics data and rare disease genomics.

Landmark publications:

Young, A., Cole, T. J., Cheng, G., Ennis, S., Beattie, R. M., & Johnson, M. J. (2022). Changes in the growth of very preterm infants in England 2006-2018. Archives of Disease in Childhood-Fetal and Neonatal Edition. https://doi.org/10.1136/archdischild-2022-324584

Mossotto, E., Boberska, J., Ashton, J. J., Stafford, I. S., Cheng, G., Baker, J., Borca, F., Phan, H. T. T., Coelho, T. F., Beattie, R. M., Claus, S. P., & Ennis, S. (2022). Evidence of a genetically driven metabolomic signature in actively inflamed Crohn's disease. Scientific Reports, 12(1). https://doi.org/ARTN 14101 10.1038/s41598-022-18178-9

Hurst, C. D., Cheng, G., Platt, F. M., Alder, O., Black, E. V. I., Burns, J. E., Brown, J., Jain, S., Roulson, J. A., & Knowles, M. A. (2022). Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling. Journal of Pathology Clinical Research, 8(3), 279-293. https://doi.org/10.1002/cjp2.261

Ashton, J. J., Cheng, G., Stafford, I. S., Kellermann, M., Seaby, E. G., Cummings, J. R. F., Coelho, T. A. F., Batra, A., Afzal, N. A., Beattie, R. M., & Ennis, S. (2022). Prediction of Crohn's Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker. Inflammatory Bowel Diseases. https://doi.org/10.1093/ibd/izac205

Ashton, J. J., Boukas, K., Stafford, I. S., Cheng, G., Haggarty, R., Coelho, T. A. F., Batra, A., Afzal, N. A., Williams, A. P., Polak, M. E., Beattie, R. M., & Ennis, S. (2022). Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 28(6), 912-922. https://doi.org/10.1093/ibd/izab318

Hurst, C. D., Cheng, G., Platt, F. M., Castro, M. A. A., Marzouka, N. A. D. S., Eriksson, P., Black, E. V. I., Alder, O., Lawson, A. R. J., Lindskrog, S. V., Burns, J. E., Jain, S., Roulson, J. A., Brown, J. C., Koster, J., Robertson, A. G., Martincorena, I., Dyrskjot, L., Hoglund, M., & Knowles, M. A. (2021). Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight. Cell Reports Medicine, 2(12). https://doi.org/ARTN 100472 10.1016/j.xcrm.2021.100472

Cheng, G., Chung, P. H. Y., Chan, E. K. W., So, M. T., Sham, P. C., Chemy, S. S., Tam, P. K. H., & Garcia-Barcelo, M. M. (2017). Patient complexity and genoty-pephenotype correlations in biliary atresia: a cross-sectional analysis. Bmc Medical Genomics, 10. https://doi.org/ARTN 22 10.1186/s12920-017-0259-0

Wong, J. K. L., Campbell, D., Ngo, N. D., Yeung, F., Cheng, G., Tang, C. S. M., Chung, P. H. Y., Tran, N. S., So, M. T., Cherny, S. S., Sham, P. C., Tam, P. K., & Garcia-Barcelo, M. M. (2016). Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes. Bmc Medical Genomics, 9. https://doi.org/ARTN 75 10.1186/s12920-016-0236-z

Porsch, R. M., Merello, E., De Marco, P., Cheng, G., Rodriguez, L., So, M. T., Sham, P. C., Tam, P. K., Capra, V., Cherny, S. S., Garcia-Barcelo, M. M., & Campbell, D. D. (2016). Sacral agenesis: a pilot whole exome sequencing and copy number study. Bmc Medical Genetics, 17. https://doi.org/ARTN 98 10.1186/s12881-016-0359-2

Wong, E. H. M., Cui, L., Ng, C. L., Tang, C. S. M., Liu, X. L., So, M. T., Yip, B. H. K., Cheng, G., Zhang, R. Z., Tang, W. K., Yang, W. L., Lau, Y. L., Baum, L., Kwan, P., Sun, L. D., Zuo, X. B., Ren, Y. Q., Yin, X. Y., Miao, X. P., Liu, J. J., Lui, V. C. H., Ngan, E. S. W., Yuan, Z. W., Zhang, S. W., Xia, J. L., Wang, H. L., Sun, X. B., Wang, R. Y., Chang, T., Chan, I. H. Y., Chung, P. H. Y., Zhang, X. J., Wong, K. K. Y., Cherny, S. S., Sham, P. C., Tam, P. K. H., & Garcia-Barcelo, M. M. (2013). Genome-wide copy number variation study in anorectal malformations. Human Molecular Genetics, 22(3), 621-631. https://doi.org/10.1093/hmg/dds451

Cui, L., Wong, E. H. M., Cheng, G., de Almeida, M. F., So, M. T., Sham, P. C., Cherny, S. S., Tam, P. K. H., & Garcia-Barcelo, M. M. (2013). Genetic Analyses of a Three Generation Family Segregating Hirschsprung Disease and Iris Heterochromia. Plos One, 8(6). https://doi.org/ARTN e66631

10.1371/journal.pone.0066631

Cheng, G., Tang, C. S. M., Wong, E. H. M., Cheng, W. W. C., So, M. T., Miao, X. P., Zhang, R. Z., Cui, L., Liu, X. L., Ngan, E. S. W., Lui, V. C. H., Chung, P. H. Y., Chan, I. H. Y., Liu, J. C., Zhong, W., Xia, H. M., Yu, J. K., Qiu, X., Wu, X. Z., Wang, B., Dong, X., Tou, J. F., Huang, L. M., Yi, B., Ren, H. X., Chan, E. K. W., Ye, K., O'Reilly, P. F., Wong, K. K. Y., Sham, P. C., Cherny, S. S., Tam, P. K. H., & Garcia-Barcelo, M. M. (2013). Common genetic variants regulating ADD3 gene expression alter biliary atresia risk. Journal of Hepatology, 59(6), 1285-1291. https://doi.org/10.1016/j.jhep.2013.07.021

Tang, C. S. M., Ngan, E. S. W., Tang, W. K., So, M. T., Cheng, G., Miao, X. P., Leon, T. Y. Y., Leung, B. M. C., Hui, K. J. W. S., Lui, V. H. C., Chen, Y., Chan, I. H. Y., Chung, P. H. Y., Liu, X. L., Wong, K. K. Y., Sham, P. C., Cherny, S. S., Tam, P. K. H., & Garcia-Barcelo, M. M. (2012). Mutations in the NRG1 gene are associated with Hirschsprung disease. Human Genetics, 131(1), 67-76. https://doi.org/10.1007/s00439-011-1035-4

Tang, C. S. M., Cheng, G., So, M. T., Yip, B. H. K., Miao, X. P., Wong, E. H. M., Ngan, E. S. W., Lui, V. C. H., Song, Y. Q., Chan, D., Cheung, K., Yuan, Z. W., Lei, L., Chung, P. H. Y., Liu, X. L., Wong, K. K. Y., Marshall, C. R., Scherer, S., Cherny, S. S., Sham, P. C., Tam, P. K. H., & Garcia-Barcelo, M. M. (2012). Genome-Wide Copy Number Analysis Uncovers a New HSCR Gene: NRG3. Plos Genetics, 8(5). https://doi.org/ARTN e1002687 10.1371/journal.pgen.1002687

So, M. T., Leon, T. Y. Y., Cheng, G., Tang, C. S. M., Miao, X. P., Cornes, B. K., Ngo, D. N., Cui, L., Ngan, E. S. W., Lui, V. C. H., Wu, X. Z., Wang, B., Wang, H. L., Yuan, Z. W., Huang, L. M., Li, L., Xia, H. M., Zhu, D. L., Liu, J. C., Nguyen, T. L., Chan, I. H. Y., Chung, P. H. Y., Liu, X. L., Zhang, R. Z., Wong, K. K. Y., Sham, P. C., Cherny, S. S., Tam, P. K. H., & Garcia-Barcelo, M. M. (2011). RET Mutational Spectrum in Hirschsprung Disease: Evaluation of 601 Chinese Patients. Plos One, 6(12). https://doi.org/ARTN e28986 10.1371/journal.pone.0028986

Garcia-Barcelo, M. M., Yeung, M. Y., Miao, X. P., Tang, C. S. M., Cheng, G., So, M. T., Ngan, E. W., Lui, V. C. H., Chen, Y., Liu, X. L., Hui, K. J. W. S., Li, L., Guo, W. H., Sun, X. B., Tou, J. F., Chan, K. W., Wu, X. Z., Song, Y. Q., Chan, D., Cheung, K., Chung, P. H. Y., Wong, K. K. Y., Sham, P. C., Cherny, S. S., & Tam, P. K. H. (2011). Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2 (vol 19, pg 2917, 2010). Human Molecular Genetics, 20(5), 1048-1048. https://doi.org/10.1093/hmg/ddq540